This binding inhibits the formation of thymidylate from 2'-deaxyuridylate. ![]() First, FdUMP and the folate cofactor, N5-10-methylenetetrahydrofolate, bind to thymidylate synthase (TS) to form a covalently bound ternary complex. ![]() These metabolites cause cell injury by two different mechanisms. Fluorouracil is further metabolized to two active metabolites, 5-fluoro-2'-deoxyuridine 5'-monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP), within normal and tumour cells. Oesophagogastric Cancer: Capsy is used for the first line treatment of patients with advanced oesophagogastric cancer.Ĭapsy is also used to associated treatment for these conditions: Duke's C Colon cancer, Esophageal Cancers, Hepatobiliary Cancers, Malignant Neoplasm of Stomach, Metastatic Breast Cancer, Metastatic Colorectal Carcinoma, Pancreatic Cancer Metastatic, Refractory Fallopian Tube Carcinoma, Metastatic pancreatic endocrine carcinoma, Refractory Ovarian cancer, Refractory peritoneal cancer, Refractory, metastatic Colorectal carcinomaĬapsy is a prodrug that is selectively tumour-activated to its cytotoxic moiety, fluorouracil, by thymidine phosphorylase, an enzyme found in higher concentrations in many tumors compared to normal tissues or plasma. Pancreatic Cancer: Capsy is used for the first line treatment of patients with locally advanced and metastatic pancreatic cancer in combination with gemcitabine. Monotherapy is also used for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not used. It is used for first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred.īreast Cancer: Capsy in combination with docetaxel is used for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy. Fluorouracil it then metabolized both normal and tumor cells to 5-fluoro-2′-deoxyuridine 5′-monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP).Ĭolorectal Cancer: Capsy is used for a single agent for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred. It is an orally administered systemic prodrug that has little pharmacologic activity until it is converted to fluorouracil by enzymes that are expressed in higher concentrations in many tumors. Additionally, FUTP interferes with RNA synthesis.Ĭapsy is a fluoropyrimidine carbamate with antineoplastic activity indicated for the treatment of metastatic breast cancer and colon cancer. FdUMP covalently binds to thymidylate synthase, inhibiting the formation of thymidilate, thus interfering with DNA synthesis. You should also be aware that Capsy is not safe while driving, and is not addiction.Capsy is a prodrug of fluorouracil, a pyrimidine antimetabolite, which is metabolised into 5-fluoro-2′-deoxyuridine-5′monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). Refer to the list below for further details. The section on Capsy contraindications lists all such conditions.ĭrug interactions for Capsy have been reported in the medical literature. ![]() Kidney Disease, Skin Disorders and Diseases, Heart Disease are examples of such conditions. Further, the section on Capsy related warnings talks about Capsy's effects on the liver, heart and kidney.Ĭapsy is not recommended if you suffer from certain medical conditions as it can have adverse effects. In addition, Capsy's effect is Severe during pregnancy and Severe for lactating mothers. If, however, they worsen or do not go away, please speak with your physician. Usually, these side effects of Capsy go away soon, and do not persist beyond the duration of the treatment. Detailed information has been provided in the dosage section.Īpart from the aforementioned side effects, Capsy can also lead to other problems, which have been listed below. ![]() Individual symptoms and route of administration also determines the right dosage. The optimal dosage of Capsy is largely dependent on the individual's body weight, medical history, gender and age. Capsy also has some secondary and off-label uses. Colorectal Cancer are some of its major therapeutic uses. Capsy is a prescription drug, available for use as Tablet.
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